Apixaban
(Eliquiss®)
General principles of use in children (post-cardiac surgery)
Dose is weight-based.
For an adult size person, 5 mg BID may be used.
Under some circumstances 7.5 mg BID may be used.
Dose is adjusted for renal and hepatic dysfunction.
Monitoring:
Check peak level, about 3-4 hrs after morning dose, after 4 doses.
For post-cardiac surgery children, Anti-Xa (Apixaban-specific) level is kept at 100-300 ng/ml.
For a 3-mo course (short course), repeat peak level once about 2-3 weeks later.
After that, repeat peak level is done if the dose is changed or bleeding occurs.
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