ICU: Fenaldopam

DA1 receptor agonist.
Not approved for children.

Pediatr Crit Care Med 2008;9:403-6.
n=13, in PCICU
Dose for renal effect: 0.01 - 0.2 mcg/kg/min was used
Mean infusion rate of 0.07 +/- 0.08 mcg/kg/min
Urine output increased in the first 24 hrs. (1.8 to 2.7 ml/kg/hr)
Mean BUN increased from 41 to 47.
No change in creatinine.

BMC Anesthesiology 2008
Pharmacokinetics in Children was studied.
n=77, in operating room,
To produce controlled hypotension (as a strategy to control surgical bleeding).
In the blinded stage of the study, 4 doses were given 0.05, 0.2, 0.8 & 3.2 mcg/kg/min. 0.8 & 3.2 mcg/kg/min produced hypotension.
In the open label, titration part of the study, dose range of 1.0 - 1.2 mcg/kg/min produced continued blood pressure reduction.
Doses above 1.2 mcg/kg/min did not produce additional reduction in BP, but increased HR.

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