7/11/2010

ICU: Hypertension Management (Labetalol)

Beyond Nitroprusside and Esmolol infusions...Hydrallazine and Labetalol may be used as either bolus doses or infusions.

Article 2010 PCCM Publish ahead of print describes safety of Labetalol infusion in children



Lexi-Comp:
IV intermittent dose: 0.2 - 0.5 mg/kg/dose (Range 0.2 - 1 mg/kg/dose)
IV continuous infusion: 0.2 - 1.5 mg/kg/hr (Mean 0.8 mg/kg/hr; Max 3 mg/kg/hr)
Oral: 4 mg/kg/day in 2 divided doses (max. 20-40 mg/kg/day)

Duration of action: Oral - 8-24 hrs (dose dependent) IV - 2-4 hrs
Half-life: 5-8 hrs

No comments: