Secondary hyperlipidemia - Causes

From Pediatrics 2011;128:S213-S256

Causes of Secondary Hyperlipidemia

(i) Exogenous:

   Alcohol

   Drug therapy: Steroids, Isotretinoin, Beta-blockers, some OCPs, select chemotherapy agents, select anti-retroviral agents.

(ii) Endocrine/metabolic:

   Hypothyroidism/Hypopituitarism

   Type 1 and 2, DM

   Pregnancy

   Polycystic ovarian syndrome

   Lipodystrophy

   Acute intermittent porphyria

(iii) Renal:

   Chronic renal disease

   HUS

   Nephrotic syndrome

(iv) Infectious:

   Acute viral/bacterial infections

   HIV

   Hepatitis

(v) Hepatic:

   Obstructive liver disease

   Biliary cirrhosis 

   Alagile syndrome

(vi) Inflammatory diseases:

   SLE

   JRA

(vii) Storage diseases:

   Glycogen Storage disease

   Gaucher disease

   Cystine-storage disease

   Juvenile Tay-Sachs disease

   Nieman-Pick disease

(viii) Other causes:

   Kawasaki

   Anorexia nervosa

   Post-solid organ transplant

   Childhood cancer survivors

   Progeria

   Idiopathic hypercalcemia

   Klinefelter syndrome

   Werner syndrome