12/19/2012

Secondary hyperlipidemia - Causes

From Pediatrics 2011;128:S213-S256

Causes of Secondary Hyperlipidemia
(i) Exogenous:
   Alcohol
   Drug therapy: Steroids, Isotretinoin, Beta-blockers, some OCPs, select chemotherapy agents, select anti-retroviral agents.
(ii) Endocrine/metabolic:
   Hypothyroidism/Hypopituitarism
   Type 1 and 2, DM
   Pregnancy
   Polycystic ovarian syndrome
   Lipodystrophy
   Acute intermittent porphyria
(iii) Renal:
   Chronic renal disease
   HUS
   Nephrotic syndrome
(iv) Infectious:
   Acute viral/bacterial infections
   HIV
   Hepatitis
(v) Hepatic:
   Obstructive liver disease
   Biliary cirrhosis 
   Alagile syndrome
(vi) Inflammatory diseases:
   SLE
   JRA
(vii) Storage diseases:
   Glycogen Storage disease
   Gaucher disease
   Cystine-storage disease
   Juvenile Tay-Sachs disease
   Nieman-Pick disease
(viii) Other causes:
   Kawasaki
   Anorexia nervosa
   Post-solid organ transplant
   Childhood cancer survivors
   Progeria
   Idiopathic hypercalcemia
   Klinefelter syndrome
   Werner syndrome

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